U.S. stock futures are pointing lower after indexes neared or set all-time highs yesterday; Novo Nordisk ( NVO ) stock is jumping in premarket trading after the drugmaker reported positive trial results for its amycretin weight-loss drug; Boeing ( BA ) stock is moving lower after the plane maker projected a wider-than-expected loss; American Express ( AXP ) reported fourth-quarter results that mostly met analyst projections; and Verizon Communications ( VZ ) reported Q4 revenue and profit above expectations. Here's what investors need to know today.

1. US Stock Futures Point Lower After Indexes Neared or Set All-Time Highs

U.S. stock futures are pointing lower after major indexes neared or set all-time highs yesterday on encouraging earnings reports and comments from President Donald Trump . S&P 500 futures are ticking lower after the index hit a record closing high yesterday, while Nasdaq and Dow Jones Industrial Average futures also are pointing lower after they approached their own all-time closing highs. Bitcoin ( BTCUSD ) gained more than 1% to trade above $105,000, while yields on the 10-year Treasury note are little changed. Oil and gold futures are higher.

2. Novo Nordisk Stock Surges on Weight-Loss Drug Trial Results

U.S.-listed shares of Ozempic and Wegovy maker Novo Nordisk ( NVO ) are jumping 14% in premarket trading after the Danish drugmaker reported positive Phase 1b/2a clinical trial results for its amycretin weight-loss treatment. The tests showed that amycretin, which is delivered once weekly through an injection, results in weight loss of up to 22% on 20mg after 36 weeks. U.S.-listed shares of the company have declined more than 20% over the past 12 months as investors raised concerns over other trial results.

3. Boeing Stock Slips After Plane Maker Forecasts Wider-Than-Expected Loss

Boeing ( BA ) stock is slipping more than 1% in premarket trading after the struggling aerospace firm projected a much wider-than-estimated fourth-quarter loss following a nearly two-month strike that crippled production. In preliminary results released Thursday , Boeing said it anticipates recording a fourth-quarter loss of $5.46 per share—far larger than the $1.40-per-share Visible Alpha consensus—when it issues its results next Tuesday. Boeing's projected revenue of $15.2 billion was also less than analysts' estimate of $16.3 billion.

4. American Express Q4 Results Mostly in Line With Estimates

American Express ( AXP ) stock is edging lower in premarket trading after the financial services firm reported fiscal 2024 fourth-quarter results mostly in line with analysts' expectations. The credit card giant reported quarterly net income of $2.17 billion, or $3.04 per share, on revenue of $17.18 billion. Analysts polled by Visible Alpha had expected profit of $2.17 billion, or $3.05 per share, on revenue of $17.17 billion. CEO Stephen Squeri said the company saw "stronger spending from our consumer and commercial customers during the holiday season."